منابع مشابه
Inhibition of Proliferation and Estrogen Receptor Signaling
Peroxisome proliferator-activated receptor (PPAR) is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an incidence rate as high as 70% in women of reproductive age. PPAR signaling has not be...
متن کاملInhibition of SIRT1 deacetylase suppresses estrogen receptor signaling.
Estrogen receptor alpha (ERalpha) mediates estrogen-dependent gene transcription, which plays a critical role in mammary gland development, reproduction and homeostasis. Histone acetyltransferases and class I and class II histone deacetylases (HDACs) cause posttranscriptional modification of histone proteins that participate in ERalpha signaling. Here, we report that human SIRT1, a class III HD...
متن کاملMolecular mechanism of estrogen–estrogen receptor signaling
17β-Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes. Localized at the peri-membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share simil...
متن کاملRapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.
OBJECTIVE The proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in vascular diseases, such as atherosclerosis and restenosis, after percutaneous coronary intervention. Many studies have shown that estrogen inhibits VSMC proliferation in response to vascular injury in the mouse carotid injury model. However, the mechanisms that mediate these effects remain unclear. Here,...
متن کاملNew Perspectives for Estrogen Receptor Signaling
Signaling Gender Differences of Cardiovascular Disease : New Perspectives for Estrogen Receptor Print ISSN: 0194-911X. Online ISSN: 1524-4563 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Hypertension doi: 10.1161/01.HYP.0000223064.62762.0b 2006;47:1019-1026; originally published on...
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ژورنال
عنوان ژورنال: Breast Cancer Online
سال: 2005
ISSN: 1470-9031
DOI: 10.1017/s1470903105003172